Abstract
tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8+ T cells, CD4+ T cells and B cells. Furthermore, we use data fitting to prove that the functional response regarding the lysis of breast cancer cells by NK cells has a ratio-dependent form. Additionally, we include in our model the concentration of rituximab - a monoclonal antibody that has been suggested as a potential breast cancer therapy - and test its effect, when the standard, as well as experimental dosages, are administered.
BibTex
@article{2022_breast_cancer_rituximab,
abstract = {tBregs are a newly discovered subcategory of B regulatory cells, which are generated by breast cancer, resulting in the increase of Tregs and therefore in the death of NK cells. In this study, we use a mathematical and computational approach to investigate the complex interactions between the aforementioned cells as well as CD8+ T cells, CD4+ T cells and B cells. Furthermore, we use data fitting to prove that the functional response regarding the lysis of breast cancer cells by NK cells has a ratio-dependent form. Additionally, we include in our model the concentration of rituximab - a monoclonal antibody that has been suggested as a potential breast cancer therapy - and test its effect, when the standard, as well as experimental dosages, are administered.},
author = {Bitsouni, Vasiliki and Tsilidis, Vasilis},
doi = {10.1016/j.jtbi.2021.111001},
issn = {00225193},
journal = {Journal of Theoretical Biology},
pages = {111001},
publisher = {Elsevier},
title = {Mathematical modeling of tumor-immune system interactions: the effect of rituximab on breast cancer immune response},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0022519321004215},
volume = {539},
year = {2022}
}